Syntheses of D-homo-14.BETA.-pregnan-20-ones.
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چکیده
منابع مشابه
(20S)-20-Acetamido-18-chloro-5α-pregnan-3β-yl acetate
In the title compound, C(25)H(40)ClNO(3), prepared by the thermolysis of (20S)-O,N-diacetyl-20-amino-N-chloro-3β-hydr-oxy-5α-pregnane, the three six-membered rings adopt chair conformations while the five-membered ring is in an envelope conformation. The ester group attached to ring A is in an equatorial position. All the rings are trans-fused. Intra-molecular C-H⋯O and C-H⋯Cl inter-actions occ...
متن کاملNeuroactive Steroid 3a-Hydroxy-5a-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol
Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide biochemical, electrophysiological, and behavioral evidence that several specific actions of alcohol (ethanol) are mediated by the neurosteroid 3a-hydroxy-5a-pregnan-20-one (3a,5a-THP; allopregnanolone). Systemic alcohol administration elevates 3a,5a-THP levels in the cerebral ...
متن کاملThe Neurosteroid 3a-Hydroxy-5a-Pregnan-20-One Induces Cytoarchitectural Regression in Cultured Fetal Hippocampal Neurons
The neurosteroid 3a-hyclroxy-5a-pregnan-20-one (3a,5a-THP) acts as a potent allosteric modulator and a direct activator of the GABA-chloride channel complex. This neurosteroid has also been found to protect against seizures that arise from blockade of the GABA-chloride channel complex. Because 3a,5a-THP protects against excitotoxin-induced seizure activity and because seizure activity has been ...
متن کامل20-Oxo-5 -Pregnan-3 -yl Sulfate Is a Use-Dependent NMDA Receptor Inhibitor
NMDA receptors are ligand-gated ion channels permeable to calcium and play a critical role in excitatory synaptic transmission, synaptic plasticity, and excitotoxicity. They are heteromeric complexes of NR1 combined with NR2A-D and/or NR3A-B subunits that are activated by glutamate and glycine and whose activity is modulated by allosteric modulators. In this study, patch-clamp recordings from h...
متن کاملPregnane glycosides from the roots of Asclepias tuberosa.
Sixteen glycosides of pregnanes, including ikemagenin, lineolon, and a new pregnane, 3beta8beta,14beta,15beta,16alpha-pentahydroxy-++ +5alpha-pregnan-20-one, termed pleurogenin, were isolated from the roots of Asclepias tuberosa. Among ikemagenin and lineolon glycosides, one (1) was a known glycoside, and eight (2-7, 10, 13) were glycosides with new combinations of ikemagenin or lineolon and kn...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1975
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.23.1834